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2.          *Shono, T., Yokoyama, N., Uesaka, T., Kuroda, J., Takeya, R., Yamasaki, T., Amano, T., Mizoguchi, M., Suzuki, S.O., Niiro, H., Miyamoto, K., Akashi, K., Iwaki, T., Sumimoto, H. and Sasaki, T. (2008) Enhanced expression of NADPH oxidase Nox4 in human gliomas and its roles in cell proliferation and survival. Int J Cancer, 123, 787-792.

3.          *Sumimoto, H. (2008) Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species. FEBS J, 275, 3249-3277.

4.          Takeya, R., Taniguchi, K., Narumiya, S. and *Sumimoto, H. (2008) The mammalian formin FHOD1 is activated through phosphorylation by ROCK and mediates thrombin-induced stress fibre formation in endothelial cells. EMBO J, 27, 618-628.

5.          Maehara, Y., Miyano, K. and *Sumimoto, H. (2009) Role for the first SH3 domain of p67phox in activation of superoxide-producing NADPH oxidases. Biochem Biophys Res Commun, 379, 589-593.

6.          Miyano, K., Koga, H., Minakami, R. and *Sumimoto, H. (2009) The insert region of the Rac GTPases is dispensable for activation of superoxide-producing NADPH oxidases. Biochem J, 422, 373-382.

7.          Ogura, K., Tandai, T., Yoshinaga, S., Kobashigawa, Y., Kumeta, H., Ito, T., Sumimoto, H. and *Inagaki, F. (2009) NMR structure of the heterodimer of Bem1 and Cdc24 PB1 domains from Saccharomyces cerevisiae. J Biochem, 146, 317-325.

8.          Sumimoto, H., Minakami, R. and Miyano, K. (2009) The Nox family of NADPH oxidases that deliberately produce reactive oxygen species. In: Free Radical Biology in Digestive Diseases, (Eds. Yoshikawa, T, Suematsu, M and Naito, Y). Karger AG, Basel, in press.

9.          Taniguchi, K., Takeya, R., Suetsugu, S., Kan, O.M., Narusawa, M., Shiose, A., Tominaga, R. and *Sumimoto, H. (2009) Mammalian formin fhod3 regulates actin assembly and sarcomere organization in striated muscles. J Biol Chem, 284, 29873-29881.

10.      Taura, M., Miyano, K., Minakami, R., Kamakura, S., Takeya, R. and *Sumimoto, H. (2009) A region N-terminal to the tandem SH3 domain of p47phox plays a crucial role in the activation of the phagocyte NADPH oxidase. Biochem J, 419, 329-338.

11.      Yuzawa, S., Miyano, K., Honbou, K., Inagaki, F. and *Sumimoto, H. (2009) The domain organization of p67 phox, a protein required for activation of the superoxide-producing NADPH oxidase in phagocytes. J Innate Immun, 1, 543-555.

12.      Maehara, Y., Miyano, K., Yuzawa, S., Akimoto, R., Takeya, R. and *Sumimoto, H. (2010) A conserved region between the TPR and activation domains of p67phox participates in activation of the phagocyte NADPH oxidase. J Biol Chem, in press.

13.      Minakami, R., Maehara, Y., Kamakura, S., Kumano, O., Miyano, K. and *Sumimoto, H. (2010) Membrane phospholipid metabolism during phagocytosis in human neutrophils. Genes Cells, 15, 409-424.

14.      Fujikawa, Y., Urano, Y., Komatsu, T., Hanaoka, K., Kojima, H., Terai, T., Inoue, H. and *Nagano, T. (2008) Design and synthesis of highly sensitive fluorogenic substrates for glutathione S-transferase and application for activity imaging in living cells. J Am Chem Soc, 130, 14533-14543.

15.      Yogo, T., Urano, Y., Mizushima, A., Sunahara, H., Inoue, T., Hirose, K., Iino, M., Kikuchi, K. and *Nagano, T. (2008) Selective photoinactivation of protein function through environment-sensitive switching of singlet oxygen generation by photosensitizer. Proc Natl Acad Sci USA, 105, 28-32.

16.      Izumi, S., Urano, Y., Hanaoka, K., Terai, T. and *Nagano, T. (2009) A simple and effective strategy to increase the sensitivity of fluorescence probes in living cells. J Am Chem Soc, 131, 10189-10200.

17.      *Kobayashi, H., Ogawa, M., Kosaka, N., Choyke, P.L. and Urano, Y. (2009) Multicolor imaging of lymphatic function with two nanomaterials: quantum dot-labeled cancer cells and dendrimer-based optical agents. Nanomedicine, 4, 411-419.

18.      Koide, Y., Urano, Y., Yatsushige, A., Hanaoka, K., Terai, T. and *Nagano, T. (2009) Design and development of enzymatically activatable photosensitizer based on unique characteristics of thiazole orange. J Am Chem Soc, 131, 6058-6059.

19.      Komatsu, T., Urano, Y., Fujikawa, Y., Kobayashi, T., Kojima, H., Terai, T., Hanaoka, K. and *Nagano, T. (2009) Development of 2,6-carboxy-substituted boron dipyrromethene (BODIPY) as a novel scaffold of ratiometric fluorescent probes for live cell imaging. Chem Commun, 7015-7017.

20.      *Urano, Y., Asanuma, D., Hama, Y., Koyama, Y., Barrett, T., Kamiya, M., Nagano, T., Watanabe, T., Hasegawa, A., Choyke, P.L. and Kobayashi, H. (2009) Selective molecular imaging of viable cancer cells with pH-activatable fluorescence probes. Nature Med, 15, 104-109.

21.      *Kobayashi, H., Ogawa, M., Alford, R., Choyke, P.L. and Urano, Y. (2010) New strategies for fluorescent probe design in medical diagnostic imaging. Chem Rev, 110, 2620-2640.

22.      Takakura, H., Sasakura, K., Ueno, T., Urano, Y., Terai, T., Hanaoka, K., Tsuboi, T. and *Nagano, T. (2010) Development of luciferin analogues bearing an amino group and their application as BRET donors. Chem Asian J, in press.

23.      Togashi, M., Urano, Y., Kojima, H., Terai, T., Hanaoka, K., Igarashi, K., Hirata, Y. and *Nagano, T. (2010) Sensitive detection of acrolein in serum using time-resolved luminescence. Org Lett, 12, 1704-1707.

24.      Yogo, T., Urano, Y., Kamiya, M., Sano, K. and *Nagano, T. (2010) Development of enzyme-activated photosensitizer based on intramolecular electron transfer. Bioorg Med Chem Lett, 20, 4320-4323.

25.      Hayashi, Y., Yoshida, M., Yamato, M., *Ide, T., Wu, Z., Ochi-Shindou, M., Kanki, T., Kang, D., Sunagawa, K., Tsutsui, H. and Nakanishi, H. (2008) Reverse of age-dependent memory impairment and mitochondrial DNA damage in microglia by an overexpression of human mitochondrial transcription factor a in mice. J Neurosci, 28, 8624-8634.

26.      *Makita, N., Behr, E., Shimizu, W., Horie, M., Sunami, A., Crotti, L., Schulze-Bahr, E., Fukuhara, S., Mochizuki, N., Makiyama, T., Itoh, H., Christiansen, M., McKeown, P., Miyamoto, K., Kamakura, S., Tsutsui, H., Schwartz, P.J., George, A.L., Jr. and Roden, D.M. (2008) The E1784K mutation in SCN5A is associated with mixed clinical phenotype of type 3 long QT syndrome. J Clin Invest, 118, 2219-2229.

27.      *Tsutsui, H., Kinugawa, S. and Matsushima, S. (2008) Oxidative stress and mitochondrial DNA damage in heart failure. Circ J, 72 Suppl A, A31-37.

28.      Tsutsumi, T., *Ide, T., Yamato, M., Kudou, W., Andou, M., Hirooka, Y., Utsumi, H., Tsutsui, H. and Sunagawa, K. (2008) Modulation of the myocardial redox state by vagal nerve stimulation after experimental myocardial infarction. Cardiovasc Res, 77, 713-721.

29.      Wu, Y.W., Naya, M., Tsukamoto, T., Komatsu, H., Morita, K., Yoshinaga, K., Kuge, Y., Tsutsui, H. and *Tamaki, N. (2008) Heterogeneous reduction of myocardial oxidative metabolism in patients with ischemic and dilated cardiomyopathy using C-11 acetate PET. Circ J, 72, 786-792.

30.      Xu, Z., *Okamoto, H., Akino, M., Onozuka, H., Matsui, Y. and Tsutsui, H. (2008) Pravastatin attenuates left ventricular remodeling and diastolic dysfunction in angiotensin II-induced hypertensive mice. J Cardiovasc Pharmacol, 51, 62-70.

31.      Inoue, T., *Ide, T., Yamato, M., Yoshida, M., Tsutsumi, T., Andou, M., Utsumi, H., Tsutsui, H. and Sunagawa, K. (2009) Time-dependent changes of myocardial and systemic oxidative stress are dissociated after myocardial infarction. Free Radic Res, 43, 37-46.

32.      Matsushima, S., *Kinugawa, S., Yokota, T., Inoue, N., Ohta, Y., Hamaguchi, S. and Tsutsui, H. (2009) Increased myocardial NAD(P)H oxidase-derived superoxide causes the exacerbation of postinfarct heart failure in type 2 diabetes. Am J Physiol Heart Circ Physiol, 297, H409-416.

33.      Suga, T., *Okita, K., Morita, N., Yokota, T., Hirabayashi, K., Horiuchi, M., Takada, S., Takahashi, T., Omokawa, M., Kinugawa, S. and Tsutsui, H. (2009) Intramuscular metabolism during low-intensity resistance exercise with blood flow restriction. J Appl Physiol, 106, 1119-1124.

34.      Yokota, T., *Kinugawa, S., Hirabayashi, K., Matsushima, S., Inoue, N., Ohta, Y., Hamaguchi, S., Sobirin, M.A., Ono, T., Suga, T., Kuroda, S., Tanaka, S., Terasaki, F., Okita, K. and Tsutsui, H. (2009) Oxidative stress in skeletal muscle impairs mitochondrial respiration and limits exercise capacity in type 2 diabetic mice. Am J Physiol Heart Circ Physiol, 297, H1069-1077.

35.      Nishioka, T., Onishi, K., Shimojo, N., Nagano, Y., Matsusaka, H., Ikeuchi, M., Ide, T., Tsutsui, H., Hiroe, M., Yoshida, T. and *Imanaka-Yoshida, K. (2010) Tenascin-C may aggravate left ventricular remodeling and function after myocardial infarction in mice. Am J Physiol Heart Circ Physiol, 298, H1072-1078.

36.      Suga, T., *Okita, K., Morita, N., Yokota, T., Hirabayashi, K., Horiuchi, M., Takada, S., Omokawa, M., Kinugawa, S. and Tsutsui, H. (2010) Dose effect on intramuscular metabolic stress during low-intensity resistance exercise with blood flow restriction. J Appl Physiol, 108, 1563-1567.

37.      *Tsutsui, H., Kinugawa, S., Matsushima, S. (2010) Mitochondrial oxidative stress and dysfunction in myocardial remodelling. Cardiovasc Res, 81, 449-456.

38.      Ylikallio, E., Tyynismaa, H., Tsutsui, H., Ide, T. and *Suomalainen, A. (2010) High mitochondrial DNA copy number has detrimental effects in mice. Hum Mol Genet, 19, 2695-2705.

39.      Fukuoh, A., Ohgaki, K., Hatae, H., Kuraoka, I., Aoki, Y., Uchiumi, T., Jacobs, H.T. and *Kang, D. (2009) DNA conformation-dependent activities of human mitochondrial RNA polymerase. Genes Cells, 14, 1029-1042.

40.      Fukuoh, A. and *Kang, D. (2009) Methods for assessing binding of mitochondrial transcription factor A (TFAM) to DNA. Methods Mol Biol, 554, 87-101.

41.      Kanki, T., Kang, D. and *Klionsky, D.J. (2009) Monitoring mitophagy in yeast: the Om45-GFP processing assay. Autophagy, 5, 1186-1189.

42.      Pohjoismaki, J.L., Goffart, S., Tyynismaa, H., Willcox, S., Ide, T., Kang, D., Suomalainen, A., Karhunen, P.J., Griffith, J.D., Holt, I.J. and *Jacobs, H.T. (2009) Human heart mitochondrial DNA is organized in complex catenated networks containing abundant four-way junctions and replication forks. J Biol Chem, 284, 21446-21457.

43.      Sumitani, M., Kasashima, K., Ohta, E., Kang, D. and *Endo, H. (2009) Association of a novel mitochondrial protein M19 with mitochondrial nucleoids. J Biochem, 146, 725-732.

44.      *Uchiumi, T., Ohgaki, K., Yagi, M., Aoki, Y., Sakai, A., Matsumoto, S. and *Kang, D. (2010) ERAL1 is associated with mitochondrial ribosome and elimination of ERAL1 leads to mitochondrial dysfunction and growth retardation. Nucleic Acids Res, in press.

45.      Yamaguchi, T., Ikeda, Y., Abe, Y., Kuma, H., Kang, D., Hamasaki, N. and *Hirai, T. (2010) Structure of the membrane domain of human erythrocyte anion exchanger 1 revealed by electron crystallography. J Mol Biol, 397, 179-189.

46.      Hara, K., Shimizu, T., Unzai, S., Akashi, S., Sato, M. and *Hashimoto, H. (2009) Purification, crystallization and initial X-ray diffraction study of human REV7 in complex with a REV3 fragment. Acta Crystallogr Sect F Struct Biol Cryst Commun, 65, 1302-1305.

47.      *Hashimoto, H., Kawaguchi, S., Hara, K., Nakamura, K., Shimizu, T., Tamaru, Y. and Sato, M. (2009) Purification, crystallization and initial X-ray diffraction study of the zinc-finger domain of zebrafish Nanos. Acta Crystallogr Sect F Struct Biol Cryst Commun, 65, 959-961.

48.      Hishiki, A., *Hashimoto, H., Hanafusa, T., Kamei, K., Ohashi, E., Shimizu, T., Ohmori, H. and Sato, M. (2009) Structural basis for novel interactions between human translesion synthesis polymerases and proliferating cell nuclear antigen. J Biol Chem, 284, 10552-10560.

49.      Oroguchi, T., Hashimoto, H., Shimizu, T., Sato, M. and *Ikeguchi, M. (2009) Intrinsic dynamics of restriction endonuclease EcoO109I studied by molecular dynamics simulations and X-ray scattering data analysis. Biophys J, 96, 2808-2822.

50.      Hara, K., *Hashimoto, H., Murakumo, Y., Kobayashi, S., Kogame, T., Unzai, S., Akashi, S., Takeda, S., Shimizu, T. and Sato, M. (2010) Crystal structure of human REV7 in complex with a human REV3 fragment and structural implication of the interaction between DNA polymerase zeta and REV1. J Biol Chem, 285, 12299-12307.

51.      Oda, T., Hashimoto, H., Kuwabara, N., Akashi, S., Hayashi, K., Kojima, C., Wong, H.L., Kawasaki, T., Shimamoto, K., Sato, M. and *Shimizu, T. (2010) Structure of the N-terminal regulatory domain of a plant NADPH oxidase and its functional implications. J Biol Chem, 285, 1435-1445.

52.      *Yanagihara, I., Nakahira, K., Yamane, T., Kaieda, S., Mayanagi, K., Hamada, D., Fukui, T., Ohnishi, K., Kajiyama, S., Shimizu, T., Sato, M., Ikegami, T., Ikeguchi, M., Honda, T. and Hashimoto, H. (2010) Structure and functional characterization of Vibrio parahaemolyticus thermostable direct hemolysin. J Biol Chem, 285, 16267-16274.

53.      Asaba, T., *Suzuki, T., Ueda, R., Tsumoto, H., Nakagawa, H. and *Miyata, N. (2009) Inhibition of human sirtuins by in situ generation of an acetylated lysine-ADP-ribose conjugate. J Am Chem Soc, 131, 6989-6996.

54.      Hishikawa, K., *Nakagawa, H., Furuta, T., Fukuhara, K., Tsumoto, H., Suzuki, T. and *Miyata, N. (2009) Photoinduced nitric oxide release from a hindered nitrobenzene derivative by two-photon excitation. J Am Chem Soc, 131, 7488-7489.

55.      *Suzuki, N., Suzuki, T., Ota, Y., Nakano, T., Kurihara, M., Okuda, H., Yamori, T., Tsumoto, H., Nakagawa, H. and *Miyata, N. (2009) Design, synthesis, and biological activity of boronic acid-based histone deacetylase inhibitors. J Med Chem, 52, 2909-2922.

56.      Ueda, R., *Suzuki, T., Mino, K., Tsumoto, H., Nakagawa, H., Hasegawa, M., Sasaki, R., Mizukami, T. and *Miyata, N. (2009) Identification of cell-active lysine specific demethylase 1-selective inhibitors. J Am Chem Soc, 131, 17536-17537.

57.      Hishikawa, K., *Nakagawa, H., Furuta, T., Fukuhara, K., Tsumoto, H., Suzuki, T. and *Miyata, N. (2010) Multiple bond-conjugated photoinduced nitric oxide releaser working with two-photon excitation. Bioorg Med Chem Lett, 20, 302-305.

58.      Matsuo, K., *Nakagawa, H., Adachi, Y., Kameda, E., Tsumoto, H., Suzuki, T. and *Miyata, N. (2010) Alternative photoinduced release of HNO or NO from an acyl nitroso compound, depending on environmental polarity. Chem Commun, 46, 3788-3790.

59.      *Suzuki, T., Ota, Y., Kasuya, T., Mutsuga, M., Kawamura, Y., Tsumoto, H., Nakagawa, H., *Finn, M.G. and *Miyata, N. (2010) An unexpected example of copper-mediated in situ click chemistry. Angew Chem Int Ed Engl, in press.

60.      Kurusu, T., Hamada, J., Nokajima, H., Kitagawa, Y., Kiyoduka, M., Takahashi, A., Hanamata, S., Ohno, R., Hayashi, T., Okada, K., Koga, J., Hirochika, H., Yamane, H. and *Kuchitsu, K. (2010) Regulation of microbe-associated molecular pattern-induced hypersensitive cell death, phytoalexin production, and defense gene expression by calcineurin B-like protein-interacting protein kinases, OsCIPK14/15, in rice cultured cells. Plant Physiol, 153, 678-692. ［同誌EditorによりOn the Inside欄にて紹介］

61.      Kurusu, T., Hamada, J., Hamada, H., Hanamata, S. and *Kuchitsu, K. (2010) Roles of calcineurin B-like protein-interacting protein kinases in innate immunity in rice. Plant Signal Behav, in press.

62.      Alam, M.S., Zaki, M.H., Sawa, T., Islam, S., Ahmed, K.A., Fujii, S., Okamoto, T. and *Akaike, T. (2008) Nitric oxide produced in Peyer's patches exhibits antiapoptotic activity contributing to an antimicrobial effect in murine salmonellosis. Microbiol Immunol, 52, 197-208.

63.      Ishima, Y., Akaike, T., Kragh-Hansen, U., Hiroyama, S., Sawa, T., Suenaga, A., Maruyama, T., Kai, T. and *Otagiri, M. (2008) S-Nitrosylated human serum albumin-mediated cytoprotective activity is enhanced by fatty acid binding. J Biol Chem, 283, 34966-34975.

64.      Kaneko, K., Akuta, T., Sawa, T., Kim, H.W., Fujii, S., Okamoto, T., Nakayama, H., Ohigashi, H., Murakami, A. and *Akaike, T. (2008) Mutagenicity of 8-nitroguanosine, a product of nitrative nucleoside modification by reactive nitrogen oxides, in mammalian cells. Cancer Lett, 262, 239-247.

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67.      Urano, T., Ito, Y., Akao, M., Sawa, T., Miyata, K., Tabata, M., Morisada, T., Hato, T., Yano, M., Kadomatsu, T., Yasunaga, K., Shibata, R., Murohara, T., Akaike, T., Tanihara, H., Suda, T. and *Oike, Y. (2008) Angiopoietin-related growth factor enhances blood flow via activation of the ERK1/2-eNOS-NO pathway in a mouse hind-limb ischemia model. Arterioscler Thromb Vasc Biol, 28, 827-834.

68.      Yoshitake, J., Kato, K., Yoshioka, D., Sueishi, Y., Sawa, T., Akaike, T. and *Yoshimura, T. (2008) Suppression of NO production and 8-nitroguanosine formation by phenol-containing endocrine-disrupting chemicals in LPS-stimulated macrophages: involvement of estrogen receptor-dependent or -independent pathways. Nitric Oxide, 18, 223-228.

69.      Zaki, M.H., Fujii, S., Okamoto, T., Islam, S., Khan, S., Ahmed, K.A., Sawa, T. and *Akaike, T. (2009) Cytoprotective function of heme oxygenase 1 induced by a nitrated cyclic nucleotide formed during murine salmonellosis. J Immunol, 182, 3746-3756.

70.      Ahmed, K., Sawa, T. and *Akaike, T. (2010) Protein cysteine S-guanylation and electrophilic signal transduction by endogenous nitronucleotides. Amino Acids, in press.

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72.      Fujii, S., Sawa, T., Ihara, H., Tong, K.I., Ida, T., Okamoto, T., Ahtesham, A.K., Ishima, Y., Motohashi, H., Yamamoto, M. and *Akaike, T. (2010) The critical role of nitric oxide signaling, via protein S-guanylation and nitrated cyclic GMP, in the antioxidant adaptive response. J Biol Chem, 285, 23970-23984.

73.      Kurauchi, Y., Hisatsune, A., Isohama, Y., Sawa, T., Akaike, T., Shudo, K. and *Katsuki, H. (2010) Midbrain dopaminergic neurons utilize nitric oxide/cyclic GMP signaling to recruit ERK that links retinoic acid receptor stimulation to up-regulation of BDNF. J Neurochem, in press.

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87.      Murugan, R.S., Uchida, K., Hara, Y. and *Nagini, S. (2008) Black tea polyphenols modulate xenobiotic-metabolizing enzymes, oxidative stress and adduct formation in a rat hepatocarcinogenesis model. Free Radic Res, 42, 873-884.

88.      Shibata, T., Nakahara, H., Kita, N., Matsubara, Y., Han, C., Morimitsu, Y., Iwamoto, N., Kumagai, Y., Nishida, M., Kurose, H., Aoki, N., Ojika, M. and *Uchida, K. (2008) A food-derived synergist of NGF signaling: identification of protein tyrosine phosphatase 1B as a key regulator of NGF receptor-initiated signal transduction. J Neurochem, 107, 1248-1260.

89.      Takahashi, N., Mizuno, Y., Kozai, D., Yamamoto, S., Kiyonaka, S., Shibata, T., Uchida, K. and *Mori, Y. (2008) Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators. Channels, 2, 287-298.

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180.  Sopasakis, V.R., Liu, P., Suzuki, R., Kondo, T., Winnay, J., Tran, T.T., Asano, T., Smyth, G., Sajan, M.P., Farese, R.V., *Kahn, C.R. and Zhao, J.J. (2010) Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation. Cell Metab, 11, 220-230.

181.  Tsuchiya, Y., Asano, T., Nakayama, K., Kato, T., Karin, M. and *Kamata, H. (2010) IKK beta is an adaptor protein for beta-TrCP mediated I kappa B alpha ubiquitination in UV-induced NF-kappa B activation. Mol Cell, in press.

182.  Nishida, M., Sato, Y., Uemura, A., Narita, Y., Tozaki-Saitoh, H., Nakaya, M., Ide, T., Suzuki, K., Inoue, K., Nagao, T. and *Kurose, H. (2008) P2Y6 receptor-Galpha12/13 signalling in cardiomyocytes triggers pressure overload-induced cardiac fibrosis. EMBO J, 27, 3104-3115.

183.  Kiyonaka, S., Kato, K., Nishida, M., Mio, K., Numaga, T., Sawaguchi, Y., Yoshida, T., Wakamori, M., Mori, E., Numata, T., Ishii, M., Takemoto, H., Ojida, A., Watanabe, K., Uemura, A., Kurose, H., Morii, T., Kobayashi, T., Sato, Y., Sato, C., Hamachi, I. and *Mori, Y. (2009) Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound. Proc Natl Acad Sci USA, 106, 5400-5405.

184.  Kinoshita, H., *Kuwahara, K., Nishida, M., Jian, Z., Rong, X., Kiyonaka, S., Kuwabara, Y., Kurose, H., Inoue, R., Mori, Y., Li, Y., Nakagawa, Y., Usami, S., Fujiwara, M., Yamada, Y., Minami, T., Ueshima, K. and Nakao, K. (2010) Inhibition of TRPC6 channel activity contributes to the antihypertrophic effects of natriuretic peptides-guanylyl cyclase-A signaling in the heart. Circ Res, 106, 1849-1860.

185.  Nishida, M., Suda, R., Nagamatsu, Y., Tanabe, S., Onohara, N., Nakaya, M., Kanaho, Y., Shibata, T., Uchida, K., Sumimoto, H., Sato, Y. and *Kurose, H. (2010) Pertussis toxin up-regulates angiotensin type 1 receptors through Toll-like receptor 4-mediated Rac activation. J Biol Chem, 285, 15268-15277.

186.  Nishida, M., Watanabe, K., Sato, Y., Nakaya, M., Kitajima, N., Ide, T., Inoue, R. and *Kurose, H. (2010) Phosphorylation of TRPC6 channels at Thr69 is required for anti-hypertrophic effects of phosphodiesterase 5 inhibition. J Biol Chem, 285, 13244-13253.

187.  Numaga, T., Nishida, M., Kiyonaka, S., Kato, K., Katano, M., Mori, E., Kurosaki, T., Inoue, R., Hikida, M., Putney, J.W., Jr. and *Mori, Y. (2010) Ca²⁺ influx and protein scaffolding via TRPC3 sustain PKCbeta and ERK activation in B cells. J Cell Sci, 123, 927-938.

188.  Harusato, A., *Naito, Y., Takagi, T., Yamada, S., Mizushima, K., Hirai, Y., Horie, R., Inoue, K., Fukumoto, K., Hirata, I., Omatsu, T., Kishimoto, E., Uchiyama, K., Handa, O., Ishikawa, T., Kokura, S., Ichikawa, H., Muto, A., Igarashi, K. and Yoshikawa, T. (2009) Inhibition of Bach1 ameliorates indomethacin-induced intestinal injury in mice. J Physiol Pharmacol, 60 Suppl 7, 149-154.

189.  Okada, S., Muto, A., Ogawa, E., Nakanome, A., Katoh, Y., Ikawa, S., Aiba, S., Igarashi, K. and *Okuyama, R. (2010) Bach1-dependent and -independent Regulation of Heme Oxygenase-1 in Keratinocytes. J Biol Chem, 285, 23581-23589.

190.  *Kawai-Yamada, M., Hori, Z., Ogawa, T., Ihara-Ohori, Y., Tamura, K., Nagano, M., Ishikawa, T. and Uchimiya, H. (2009) Loss of calmodulin binding to Bax inhibitor-1 affects Pseudomonas-mediated hypersensitive response-associated cell death in Arabidopsis thaliana. J Biol Chem, 284, 27998-28003.

191.  Nagano, M., Ihara-Ohori, Y., Imai, H., Inada, N., Fujimoto, M., Tsutsumi, N., Uchimiya, H. and *Kawai-Yamada, M. (2009) Functional association of cell death suppressor, Arabidopsis Bax inhibitor-1, with fatty acid 2-hydroxylation through cytochrome b. Plant J, 58, 122-134.

192.  *Takahashi, H., Takahara, K., Hashida, S.N., Hirabayashi, T., Fujimori, T., Kawai-Yamada, M., Yamaya, T., Yanagisawa, S. and Uchimiya, H. (2009) Pleiotropic modulation of carbon and nitrogen metabolism in Arabidopsis plants overexpressing the NAD kinase2 gene. Plant Physiol, 151, 100-113.

193.  Ishikawa, T., Takahara, K., Hirabayashi, T., Matsumura, H., Fujisawa, S., Terauchi, R., Uchimiya, H. and *Kawai-Yamada, M. (2010) Metabolome analysis of response to oxidative stress in rice suspension cells overexpressing cell death suppressor Bax inhibitor-1. Plant Cell Physiol, 51, 9-20.

194.  Takahara, K., Kasajima, I., Takahashi, H., Hashida, S.N., Itami, T., Onodera, H., Toki, S., Yanagisawa, S., *Kawai-Yamada, M. and Uchimiya, H. (2010) Metabolome and photochemical analysis of rice plants overexpressing Arabidopsis NAD kinase gene. Plant Physiol, 152, 1863-1873.

195.  Watanabe, S. and *Wakasugi, K. (2009) Functional characterization of neuroglobin, a novel member of the vertebrate globin family. J Biol Inorg Chem, 14, S171.

196.  Watanabe, S. and *Wakasugi, K. (2010) Identification of residues critical for the cell-membrane-penetrating activity of zebrafish neuroglobin. FEBS Lett, 584, 2467-2472.

197.  Cekic, C., Casella, C.R., Eaves, C.A., Matsuzawa, A., Ichijo, H. and *Mitchell, T.C. (2009) Selective activation of the p38 MAPK pathway by synthetic monophosphoryl lipid A. J Biol Chem, 284, 31982-31991.

198.  Iriyama, T., Takeda, K., Nakamura, H., Morimoto, Y., Kuroiwa, T., Mizukami, J., Umeda, T., Noguchi, T., Naguro, I., Nishitoh, H., Saegusa, K., Tobiume, K., Homma, T., Shimada, Y., Tsuda, H., Aiko, S., Imoto, I., Inazawa, J., Chida, K., Kamei, Y., Kozuma, S., Taketani, Y., Matsuzawa, A. and *Ichijo, H. (2009) ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis. EMBO J, 28, 843-853.

199.  Nagai, H., Noguchi, T., Homma, K., Katagiri, K., Takeda, K., Matsuzawa, A. and *Ichijo, H. (2009) Ubiquitin-like sequence in ASK1 plays critical roles in the recognition and stabilization by USP9X and oxidative stress-induced cell death. Mol Cell, 36, 805-818.

200.  Katagiri, K., Matsuzawa, A. and *Ichijo, H. (2010) Regulation of apoptosis signal-regulating kinase 1 in redox signaling. Methods Enzymol, 474, 277-288.

201.  Maruyama, T., Kadowaki, H., Okamoto, N., Nagai, A., Naguro, I., Matsuzawa, A., Shibuya, H., Tanaka, K., Murata, S., Takeda, K., *Nishitoh, H. and *Ichijo, H. (2010) CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response. EMBO J, in press.

202.  Tseng, P.H., Matsuzawa, A., Zhang, W., Mino, T., Vignali, D.A. and *Karin, M. (2010) Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines. Nature Immunol, 11, 70-75.

203.  Kaneko, T., Hamazaki, J., Iemura, S., Sasaki, K., Furuyama, K., Natsume, T., Tanaka, K. and *Murata, S. (2009) Assembly pathway of the mammalian proteasome base subcomplex is mediated by multiple specific chaperones. Cell, 137, 914-925.

204.  Nishio, K., Kim, S.W., Kawai, K., Mizushima, T., Yamane, T., Hamazaki, J., Murata, S., *Tanaka, K. and *Morimoto, Y. (2009) Crystal structure of the de-ubiquitinating enzyme UCH37 (human UCH-L5) catalytic domain. Biochem Biophys Res Commun, 390, 855-860.

205.  Tokui, K., *Adachi, H., Waza, M., Katsuno, M., Minamiyama, M., Doi, H., Tanaka, K., Hamazaki, J., Murata, S., Tanaka, F. and *Sobue, G. (2009) 17-DMAG ameliorates polyglutamine-mediated motor neuron degeneration through well-preserved proteasome function in an SBMA model mouse. Hum Mol Genet, 18, 898-910.

206.  Tonoki, A., Kuranaga, E., Tomioka, T., Hamazaki, J., Murata, S., Tanaka, K. and *Miura, M. (2009) Genetic evidence linking age-dependent attenuation of the 26S proteasome with the aging process. Mol Cell Biol, 29, 1095-1106.

207.  Sasaki, K., Hamazaki, J., Koike, M., Hirano, Y., Komatsu, M., Uchiyama, Y., Tanaka, K. and *Murata, S. (2010) PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasis. Mol Cell Biol, 30, 3864-3874.

208.  Hiatt, S.M., Duren, H.M., Shyu, Y.J., Ellis, R.E., Hisamoto, N., Matsumoto, K., Kariya, K., Kerppola, T.K. and *Hu, C.D. (2009) Caenorhabditis elegans FOS-1 and JUN-1 regulate plc-1 expression in the spermatheca to control ovulation. Mol Biol Cell, 20, 3888-3895.

209.  Saha, S., Guillily, M.D., Ferree, A., Lanceta, J., Chan, D., Ghosh, J., Hsu, C.H., Segal, L., Raghavan, K., Matsumoto, K., Hisamoto, N., Kuwahara, T., Iwatsubo, T., Moore, L., Goldstein, L., Cookson, M. and *Wolozin, B. (2009) LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans. J Neurosci, 29, 9210-9218.

210.  Schouest, K.R., Kurasawa, Y., Furuta, T., Hisamoto, N., Matsumoto, K. and *Schumacher, J.M. (2009) The germinal center kinase GCK-1 is a negative regulator of MAP kinase activation and apoptosis in the C. elegans germline. PLoS One, 4, e7450.

211.  Fujiki, K., Mizuno, T., Hisamoto, N. and *Matsumoto, K. (2010) The Caenorhabditis elegans Ste20-related kinase and Rac-type small GTPase regulate the c-Jun N-terminal kinase signaling pathway mediating the stress response. Mol Cell Biol, 30, 995-1003.

212.  Shivers, R.P., Pagano, D.J., Kooistra, T., Richardson, C.E., Reddy, K.C., Whitney, J.K., Kamanzi, O., Matsumoto, K., Hisamoto, N. and *Kim, D.H. (2010) Phosphorylation of the conserved transcription factor ATF-7 by PMK-1 p38 MAPK regulates innate immunity in Caenorhabditis elegans. PLoS Genet, 6, e1000892.

213.  Boles, M.K., Wilkinson, B.M., Wilming, L.G., Liu, B., Probst, F.J., Harrow, J., Grafham, D., Hentges, K.E., Woodward, L.P., Maxwell, A., Mitchell, K., Risley, M.D., Johnson, R., Hirschi, K., Lupski, J.R., Funato, Y., Miki, H., Marin-Garcia, P., Matthews, L., Coffey, A.J., Parker, A., Hubbard, T.J., Rogers, J., Bradley, A., Adams, D.J. and *Justice, M.J. (2009) Discovery of candidate disease genes in ENU-induced mouse mutants by large-scale sequencing, including a splice-site mutation in nucleoredoxin. PLoS Genet, 5, e1000759.

214.  Terabayashi, T., Funato, Y., Fukuda, M. and *Miki, H. (2009) A coated vesicle-associated kinase of 104 kDa (CVAK104) induces lysosomal degradation of frizzled 5 (Fzd5). J Biol Chem, 284, 26716-26724.

215.  *Funato, Y. and *Miki, H. (2010) Redox regulation of Wnt signalling via nucleoredoxin. Free Radic Res, 44, 379-388.

216.  Hayashi, T., Funato, Y., Terabayashi, T., Morinaka, A., Sakamoto, R., Ichise, H., Fukuda, H., Yoshida, N. and *Miki, H. (2010) Nucleoredoxin negatively regulates Toll-like receptor 4 signaling via recruitment of flightless-I to myeloid differentiation primary response gene (88). J Biol Chem, 285, 18586-18593.

217.  Blackwell, K., Zhang, L., Thomas, G.S., Sun, S., Nakano, H. and *Habelhah, H. (2009) TRAF2 phosphorylation modulates tumor necrosis factor alpha-induced gene expression and cell resistance to apoptosis. Mol Cell Biol, 29, 303-314.

218.  Kraus, Z.J., Nakano, H. and *Bishop, G.A. (2009) TRAF5 is a critical mediator of in vitro signals and in vivo functions of LMP1, the viral oncogenic mimic of CD40. Proc Natl Acad Sci USA, 106, 17140-17145.

219.  *Tanaka, S. and Nakano, H. (2009) NF-kappaB2 (p100) limits TNF-alpha-induced osteoclastogenesis. J Clin Invest, 119, 2879-2881.

220.  Ando, K., Hasegawa, K., Shindo, K., Furusawa, T., Fujino, T., Kikugawa, K., Nakano, H., Takeuchi, O., Akira, S., Akiyama, T., Gohda, J., Inoue, J. and *Hayakawa, M. (2010) Human lactoferrin activates NF-kappaB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling. FEBS J, 277, 2051-2066.

221.  Masszi, A., Speight, P., Charbonney, E., Lodyga, M., Nakano, H., Szaszi, K. and *Kapus, A. (2010) Fate-determining mechanisms in epithelial-myofibroblast transition: major inhibitory role for Smad3. J Cell Biol, 188, 383-399.

222.  Missiou, A., Rudolf, P., Stachon, P., Wolf, D., Varo, N., Aichele, P., Colberg, C., Hoppe, N., Ernst, S., Munkel, C., Walter, C., Sommer, G., Hilgendorf, I., Nakano, H., Bode, C. and *Zirlik, A. (2010) TRAF5 deficiency accelerates atherogenesis in mice by increasing inflammatory cell recruitment and foam cell formation. Circ Res, in press.

（corresponding authorには*を付けています）

本領域は、平成21年初頭より計画研究（12課題）を開始しました。さらに、平成21年後半より公募研究（16課題）を加えて、活性酸素シグナルの受容からエフェクター分子による制御機構の解明に向けた研究を幅広く総合的に展開しています。本年度実施予定の中間評価に向けて研究成果を取りまとめました。
詳細は研究成果をご参照下さい。

本領域の第２回公開国際シンポジウムを、第６回国際NO学会と共同で、京都国際会議場にて開催しました。領域公開国際シンポジウムでは、海外から４名の招へい演者（B. G. Hill博士［Louisville大］、M. Tarpey博士［Pittsuburgh大］、Y. J. Surh博士［Seoul国際大］、S. Shiva博士［Pittsuburgh大］）、２名の領域メンバー（松沢　厚博士、中野裕康博士）により、活性酸素研究における最新のトピックスが紹介されました。

また、共同開催の国際NO学会は、NO・活性酸素分野の最前線の研究者を集めて２年に一度開催されるもので、今回は、領域代表の赤池がPresidentとなり、海外からの参加者約１４０名を加えて、４００名近くの参加があり、活発な討論が行われました。

講演要旨は、Nitric Oxide誌（こちらから）に掲載されています。なお、上記領域シンポジウムならびに国際NO学会の開催を記念したSpecial Issueの発行が、同誌にて予定されています。

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