中間評価に向けた研究成果の取りまとめ
計画研究は平成20年度から、公募研究は平成21年度から平成22年7月までに発表した英文論文をまとめています。
１. Mayumi, M., Takeda, Y., Hoshiko, M., Serada, K., Murata, M., *Moritomo, T., Takizawa, F., Kobayashi, I., Araki, K., Nakanishi, T. and Sumimoto, H. (2008) Characterization of teleost phagocyte NADPH oxidase: molecular cloning and expression analysis of carp (Cyprinus carpio) phagocyte NADPH oxidase. Mol Immunol, 45, 1720-1731.
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5. Maehara, Y., Miyano, K. and *Sumimoto, H. (2009) Role for the first SH3 domain of p67phox in activation of superoxide-producing NADPH oxidases. Biochem Biophys Res Commun, 379, 589-593.
6. Miyano, K., Koga, H., Minakami, R. and *Sumimoto, H. (2009) The insert region of the Rac GTPases is dispensable for activation of superoxide-producing NADPH oxidases. Biochem J, 422, 373-382.
7. Ogura, K., Tandai, T., Yoshinaga, S., Kobashigawa, Y., Kumeta, H., Ito, T., Sumimoto, H. and *Inagaki, F. (2009) NMR structure of the heterodimer of Bem1 and Cdc24 PB1 domains from Saccharomyces cerevisiae. J Biochem, 146, 317-325.
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9. Taniguchi, K., Takeya, R., Suetsugu, S., Kan, O.M., Narusawa, M., Shiose, A., Tominaga, R. and *Sumimoto, H. (2009) Mammalian formin fhod3 regulates actin assembly and sarcomere organization in striated muscles. J Biol Chem, 284, 29873-29881.
10. Taura, M., Miyano, K., Minakami, R., Kamakura, S., Takeya, R. and *Sumimoto, H. (2009) A region N-terminal to the tandem SH3 domain of p47phox plays a crucial role in the activation of the phagocyte NADPH oxidase. Biochem J, 419, 329-338.
11. Yuzawa, S., Miyano, K., Honbou, K., Inagaki, F. and *Sumimoto, H. (2009) The domain organization of p67 phox, a protein required for activation of the superoxide-producing NADPH oxidase in phagocytes. J Innate Immun, 1, 543-555.
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13. Minakami, R., Maehara, Y., Kamakura, S., Kumano, O., Miyano, K. and *Sumimoto, H. (2010) Membrane phospholipid metabolism during phagocytosis in human neutrophils. Genes Cells, 15, 409-424.
14. Fujikawa, Y., Urano, Y., Komatsu, T., Hanaoka, K., Kojima, H., Terai, T., Inoue, H. and *Nagano, T. (2008) Design and synthesis of highly sensitive fluorogenic substrates for glutathione S-transferase and application for activity imaging in living cells. J Am Chem Soc, 130, 14533-14543.
15. Yogo, T., Urano, Y., Mizushima, A., Sunahara, H., Inoue, T., Hirose, K., Iino, M., Kikuchi, K. and *Nagano, T. (2008) Selective photoinactivation of protein function through environment-sensitive switching of singlet oxygen generation by photosensitizer. Proc Natl Acad Sci USA, 105, 28-32.
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18. Koide, Y., Urano, Y., Yatsushige, A., Hanaoka, K., Terai, T. and *Nagano, T. (2009) Design and development of enzymatically activatable photosensitizer based on unique characteristics of thiazole orange. J Am Chem Soc, 131, 6058-6059.
19. Komatsu, T., Urano, Y., Fujikawa, Y., Kobayashi, T., Kojima, H., Terai, T., Hanaoka, K. and *Nagano, T. (2009) Development of 2,6-carboxy-substituted boron dipyrromethene (BODIPY) as a novel scaffold of ratiometric fluorescent probes for live cell imaging. Chem Commun, 7015-7017.
20. *Urano, Y., Asanuma, D., Hama, Y., Koyama, Y., Barrett, T., Kamiya, M., Nagano, T., Watanabe, T., Hasegawa, A., Choyke, P.L. and Kobayashi, H. (2009) Selective molecular imaging of viable cancer cells with pH-activatable fluorescence probes. Nature Med, 15, 104-109.
21. *Kobayashi, H., Ogawa, M., Alford, R., Choyke, P.L. and Urano, Y. (2010) New strategies for fluorescent probe design in medical diagnostic imaging. Chem Rev, 110, 2620-2640.
22. Takakura, H., Sasakura, K., Ueno, T., Urano, Y., Terai, T., Hanaoka, K., Tsuboi, T. and *Nagano, T. (2010) Development of luciferin analogues bearing an amino group and their application as BRET donors. Chem Asian J, in press.
23. Togashi, M., Urano, Y., Kojima, H., Terai, T., Hanaoka, K., Igarashi, K., Hirata, Y. and *Nagano, T. (2010) Sensitive detection of acrolein in serum using time-resolved luminescence. Org Lett, 12, 1704-1707.
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30. Xu, Z., *Okamoto, H., Akino, M., Onozuka, H., Matsui, Y. and Tsutsui, H. (2008) Pravastatin attenuates left ventricular remodeling and diastolic dysfunction in angiotensin II-induced hypertensive mice. J Cardiovasc Pharmacol, 51, 62-70.
31. Inoue, T., *Ide, T., Yamato, M., Yoshida, M., Tsutsumi, T., Andou, M., Utsumi, H., Tsutsui, H. and Sunagawa, K. (2009) Time-dependent changes of myocardial and systemic oxidative stress are dissociated after myocardial infarction. Free Radic Res, 43, 37-46.
32. Matsushima, S., *Kinugawa, S., Yokota, T., Inoue, N., Ohta, Y., Hamaguchi, S. and Tsutsui, H. (2009) Increased myocardial NAD(P)H oxidase-derived superoxide causes the exacerbation of postinfarct heart failure in type 2 diabetes. Am J Physiol Heart Circ Physiol, 297, H409-416.
33. Suga, T., *Okita, K., Morita, N., Yokota, T., Hirabayashi, K., Horiuchi, M., Takada, S., Takahashi, T., Omokawa, M., Kinugawa, S. and Tsutsui, H. (2009) Intramuscular metabolism during low-intensity resistance exercise with blood flow restriction. J Appl Physiol, 106, 1119-1124.
34. Yokota, T., *Kinugawa, S., Hirabayashi, K., Matsushima, S., Inoue, N., Ohta, Y., Hamaguchi, S., Sobirin, M.A., Ono, T., Suga, T., Kuroda, S., Tanaka, S., Terasaki, F., Okita, K. and Tsutsui, H. (2009) Oxidative stress in skeletal muscle impairs mitochondrial respiration and limits exercise capacity in type 2 diabetic mice. Am J Physiol Heart Circ Physiol, 297, H1069-1077.
35. Nishioka, T., Onishi, K., Shimojo, N., Nagano, Y., Matsusaka, H., Ikeuchi, M., Ide, T., Tsutsui, H., Hiroe, M., Yoshida, T. and *Imanaka-Yoshida, K. (2010) Tenascin-C may aggravate left ventricular remodeling and function after myocardial infarction in mice. Am J Physiol Heart Circ Physiol, 298, H1072-1078.
36. Suga, T., *Okita, K., Morita, N., Yokota, T., Hirabayashi, K., Horiuchi, M., Takada, S., Omokawa, M., Kinugawa, S. and Tsutsui, H. (2010) Dose effect on intramuscular metabolic stress during low-intensity resistance exercise with blood flow restriction. J Appl Physiol, 108, 1563-1567.
37. *Tsutsui, H., Kinugawa, S., Matsushima, S. (2010) Mitochondrial oxidative stress and dysfunction in myocardial remodelling. Cardiovasc Res, 81, 449-456.
38. Ylikallio, E., Tyynismaa, H., Tsutsui, H., Ide, T. and *Suomalainen, A. (2010) High mitochondrial DNA copy number has detrimental effects in mice. Hum Mol Genet, 19, 2695-2705.
39. Fukuoh, A., Ohgaki, K., Hatae, H., Kuraoka, I., Aoki, Y., Uchiumi, T., Jacobs, H.T. and *Kang, D. (2009) DNA conformation-dependent activities of human mitochondrial RNA polymerase. Genes Cells, 14, 1029-1042.
40. Fukuoh, A. and *Kang, D. (2009) Methods for assessing binding of mitochondrial transcription factor A (TFAM) to DNA. Methods Mol Biol, 554, 87-101.
41. Kanki, T., Kang, D. and *Klionsky, D.J. (2009) Monitoring mitophagy in yeast: the Om45-GFP processing assay. Autophagy, 5, 1186-1189.
42. Pohjoismaki, J.L., Goffart, S., Tyynismaa, H., Willcox, S., Ide, T., Kang, D., Suomalainen, A., Karhunen, P.J., Griffith, J.D., Holt, I.J. and *Jacobs, H.T. (2009) Human heart mitochondrial DNA is organized in complex catenated networks containing abundant four-way junctions and replication forks. J Biol Chem, 284, 21446-21457.
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46. Hara, K., Shimizu, T., Unzai, S., Akashi, S., Sato, M. and *Hashimoto, H. (2009) Purification, crystallization and initial X-ray diffraction study of human REV7 in complex with a REV3 fragment. Acta Crystallogr Sect F Struct Biol Cryst Commun, 65, 1302-1305.
47. *Hashimoto, H., Kawaguchi, S., Hara, K., Nakamura, K., Shimizu, T., Tamaru, Y. and Sato, M. (2009) Purification, crystallization and initial X-ray diffraction study of the zinc-finger domain of zebrafish Nanos. Acta Crystallogr Sect F Struct Biol Cryst Commun, 65, 959-961.
48. Hishiki, A., *Hashimoto, H., Hanafusa, T., Kamei, K., Ohashi, E., Shimizu, T., Ohmori, H. and Sato, M. (2009) Structural basis for novel interactions between human translesion synthesis polymerases and proliferating cell nuclear antigen. J Biol Chem, 284, 10552-10560.
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50. Hara, K., *Hashimoto, H., Murakumo, Y., Kobayashi, S., Kogame, T., Unzai, S., Akashi, S., Takeda, S., Shimizu, T. and Sato, M. (2010) Crystal structure of human REV7 in complex with a human REV3 fragment and structural implication of the interaction between DNA polymerase zeta and REV1. J Biol Chem, 285, 12299-12307.
51. Oda, T., Hashimoto, H., Kuwabara, N., Akashi, S., Hayashi, K., Kojima, C., Wong, H.L., Kawasaki, T., Shimamoto, K., Sato, M. and *Shimizu, T. (2010) Structure of the N-terminal regulatory domain of a plant NADPH oxidase and its functional implications. J Biol Chem, 285, 1435-1445.
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53. Asaba, T., *Suzuki, T., Ueda, R., Tsumoto, H., Nakagawa, H. and *Miyata, N. (2009) Inhibition of human sirtuins by in situ generation of an acetylated lysine-ADP-ribose conjugate. J Am Chem Soc, 131, 6989-6996.
54. Hishikawa, K., *Nakagawa, H., Furuta, T., Fukuhara, K., Tsumoto, H., Suzuki, T. and *Miyata, N. (2009) Photoinduced nitric oxide release from a hindered nitrobenzene derivative by two-photon excitation. J Am Chem Soc, 131, 7488-7489.
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56. Ueda, R., *Suzuki, T., Mino, K., Tsumoto, H., Nakagawa, H., Hasegawa, M., Sasaki, R., Mizukami, T. and *Miyata, N. (2009) Identification of cell-active lysine specific demethylase 1-selective inhibitors. J Am Chem Soc, 131, 17536-17537.
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58. Matsuo, K., *Nakagawa, H., Adachi, Y., Kameda, E., Tsumoto, H., Suzuki, T. and *Miyata, N. (2010) Alternative photoinduced release of HNO or NO from an acyl nitroso compound, depending on environmental polarity. Chem Commun, 46, 3788-3790.
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（corresponding authorには*を付けています）